It is a peptide of 11 amino acids and derived from the fungus Beauveria nivea.
Cyclosporin is thought to bind to the cytosolic protein cyclophilin (immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. This complex of cyclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. It also inhibits lymphokine production and interleukin release and, therefore, leads to a reduced function of effector T-cells.
Reduction of T-Cells function leads to no antibodies production and eventually no rejection of transplanted organs / no other immunological reactions.
- Cardiac transplant rejection
- Kidney transplant rejection
- Liver transplant rejection
- Small Bowel transplant rejection
- Pancreas transplant rejection
- Lung transplant rejection
- Trachea transplant rejection
- Skin transplant rejection
- Bone marrow transplant rejection
- Cornea transplant rejection
- Limb transplant rejection
- Rheumatoid Arthritis
- Eczema, particularly atopic dermatitis
- Psoriasis
- Chronic autoimmune urticaria
- Pyoderma gangrenosum
- Steroid non-responsive Ulcerative colitis
- Uveitis with non-infective etiology
Even though there were several minor side effects, the important side effect is carcinogenicity.
Another considerable effect - increase in the severity of existing Viral, fungal and bacterial infections and increased vulnerability to opportunistic fungal and viral infections.
i-CYC capsules are available in strengths of 25 mg, 50 mg, & 100 mg.
Box containing 5 Strips of 10 capsules each