Quick Product Info At A Glance
i-BIND (Calcium Polystyrene sulphonate) is used as a Potassium binder.
Mechanism of action
i-BIND (calcium polystyrene sulphonate) is a Cation exchange resin and acts by a cumulative process throughout the gastrointestinal tract, removing potassium ions and excreting in the feces.
As the i-BIND passes through the colon, it comes into contact with fluids containing increasing amounts of potassium. In the cecum the concentration of Na+ and K+ are similar to those in the small intestine. In the stool water of the sigmoid colon there may be 6-38 mmol/L sodium and 14-44 mmol/L potassium. The result is that potassium is taken up in increasing amounts inexchange for calcium ions. The length of time the resin remains in the body is a decisive factor in its effectiveness. For this reason oral administration is more effective than the use of enemas which should, if possible, be retained for 9 hours. The efficiency of potassium exchange is unpredictably variable. The resin is not selective for potassium.
Mechanism of action
i-BIND (calcium polystyrene sulphonate) is a Cation exchange resin and acts by a cumulative process throughout the gastrointestinal tract, removing potassium ions and excreting in the feces.
As the i-BIND passes through the colon, it comes into contact with fluids containing increasing amounts of potassium. In the cecum the concentration of Na+ and K+ are similar to those in the small intestine. In the stool water of the sigmoid colon there may be 6-38 mmol/L sodium and 14-44 mmol/L potassium. The result is that potassium is taken up in increasing amounts inexchange for calcium ions. The length of time the resin remains in the body is a decisive factor in its effectiveness. For this reason oral administration is more effective than the use of enemas which should, if possible, be retained for 9 hours. The efficiency of potassium exchange is unpredictably variable. The resin is not selective for potassium.
Indications
- Hyperkalemia associated with anuria or severe oliguria
- Indicated in all states of hyperkalemia due to acute and chronic renal failure; examples include use following abortion, complicated labor, incompatible blood transfusion, crush injury, prostatectomy, severe burns, surgical shock, and in cases of severe glomerulonephritis and pyelonephritis
- Hyperkalemia during Hemodialysis.
- Indicated in all states of hyperkalemia due to acute and chronic renal failure; examples include use following abortion, complicated labor, incompatible blood transfusion, crush injury, prostatectomy, severe burns, surgical shock, and in cases of severe glomerulonephritis and pyelonephritis
- Hyperkalemia during Hemodialysis.
Side effects:
Nausea, vomiting, gastric irritation, anorexia, constipation and occasionally, diarrhea.
Dosage:
1 Sachet 3 times a day.
Presentation:
Combi-pack box contains one sachet of 15 gm + 50 ml of sorbitol solution as a vehicle for administration.